2005

HK Goh, KY Tham, E Seow
Correspondence: Dr Hsin-Kai Goh, hsin_kai_goh@ttsh.com.sg

ABSTRACT
Introduction On March 13, 2003, Singapore doctors were alerted about an outbreak of atypical pneumonia that became known as severe acute respiratory syndrome (SARS). We now describe a series of patients that did not fit World Health Organisation (WHO) case definitions for SARS at initial assessment.
Methods The Ministry of Health, Singapore centralised SARS cases in the study hospital and its emergency department (ED) became the national screening centre. A screening questionnaire and a set of admission criteria based on WHO case definitions were applied. Patients discharged from ED were tracked via telephone surveillance and recalled if necessary. A retrospective review was done of patients who did not fit WHO definitions initially, were discharged and had re-attended.
Results During the outbreak, 11,461 people were screened for SARS. Among 10,075 (87.9 percent) discharged from the ED, there were 28 re-attendees diagnosed to have SARS later, giving an undertriage rate of 0.3 percent. Among the 28, six (21.4 percent) did not complain of fever and 22 (78.6 percent) had temperatures less than 38.0 degrees Celsius during their first ED visit. One patient was screened to have all three criteria but during consultation, the contact history was found to be unrelated to the known "hot spots". The initial mean temperature was 37.6 degrees Celsius (standard deviation [SD] 0.8), which increased significantly (p-value equals 0.04) to 38.0 degrees Celsius (SD 0.8) during their subsequent visit. Chest radiographs with infective changes increased significantly (p-value equals 0.009) from 16 percent to 52.4 percent over the two ED visits.
Conclusion The WHO case definitions were helpful in evaluating majority of SARS patients initially. However under-triage at ED is inevitable, with a 0.3 percent under-triage in our study population. In this group and asymptomatic individuals who came for screening, a tracking and recall system helped to ensure their timely return to the ED.

Keywords: atypical pneumonia, chest radiographs, emergency department, severe acute respiratory syndrome (SARS), World Health Organisation
Singapore Med J 2005; 46(8): 414-420

KK Poh, HC Tan, JWL Yip, YT Lim
Correspondence: Dr Poh Kian Keong, doctorpoh@yahoo.com

ABSTRACT
Introduction The pattern of use of abciximab in real-life clinical patients undergoing percutaneous coronary intervention (PCI) in 11 high-volume centres in Singapore, Malaysia, Thailand, Philippines, India, Pakistan and Korea was prospectively examined.
Methods These centres enrolled 224 consecutive patients over eight months to receive abciximab during PCI for the study. The cohort consisted of 82.1 percent males, with mean age of 55 (+/- 11) years and mean weight of 67 (+/- 17) kg.
Results The use of abciximab during PCI ranged between 6.2 percent and 21.6 percent. The indications for the use of abciximab were: acute coronary syndromes (34.3 percent), complex coronary lesions (17.9 percent) and multivessel PCI (17.7 percent). Based on a risk scoring system devised for this registry, majority (60.0 percent) of the patients was considered high risk when abciximab was used. Among the patients enrolled, 36.6 percent received abciximab as a "bail-out". The overall in-hospital ischaemic event rates were low at 4.0 percent. The complication rates included major bleeding 0.7 percent, thrombocytopenia 2.7 percent and need for blood transfusion 2.8 percent. There was a trend towards a higher incidence of in-hospital non-Q myocardial infarction in the "bail-out" group (2.1 percent versus 7.3 percent, p-value equals 0.07).
Conclusion Abxicimab was uncommonly used among patients (9.4 percent) undergoing PCI in this Asian region, with the operators reserving it mainly for high-risk patients.

Keywords: abciximab, adjuvant drug therapy, angioplasty, coronary disease, percutaneous coronary intervention
Singapore Med J 2005; 46(8): 407-413

YK Lim, TYT Tan, R Zuzarte, ML Daniel, GSH Yeo
Correspondence: Dr Tony Tan, tonytan@kkh.com.sg

ABSTRACT
Introduction To determine the perinatal outcomes of monochorionic (MC) pregnancies complicated by the twin-twin transfusion syndrome (TTTS) that were managed in a specialised twin clinic at the KK Women's and Children's Hospital.
Methods This was a 21-month retrospective study carried out from January 2002 to September 2003. MC pregnancies were followed up every two to three weeks with regular ultrasonographical and Doppler studies from the time monochorionicity was diagnosed. Standard criteria used for the diagnosis of TTTS are the presence of oligohydramnios/polyhydramnios sequence on ultrasonography. The severity of TTTS was staged according to Quintero's system.
Results There were 77 sets of MC pregnancies in our database. 11 sets were diagnosed with TTTS, hence the incidence was 14.3 percent. The median gestation at diagnosis of TTTS was 17.4 (16.4 to 26) weeks. At first presentation, five were stage I, two were stage II, three were stage III and one was stage IV. Three pregnancies were terminated in the second trimester and one was lost to follow-up. Of the other seven, two were treated expectantly or delivered, four with amnioreduction/ septostomy and one with cord occlusion. The median gestation at delivery is 30.8 (26.7 to 36.9) weeks. Four (57 percent) were delivered before 32 weeks and these same four pairs required neonatal intensive care. The overall perinatal survival was 78 percent (11/14) and the median diagnosis to delivery interval was 10.7 (3.1 to 17.5) weeks.
Conclusion TTTS occurs in a significant proportion of MC pregnancies. The perinatal survival outcome of this group of patients managed in this clinic is comparable to that of other good centres.

Keywords: monochorionic pregnancy, perinatal outcomes, perinatal survival, twin-twin transfusion syndrome, ultrasonography
Singapore Med J 2005; 46(8): 401-406

W Liu, CC Loo, JW Chiu, HM Tan, HZ Ren, Y Lim
Correspondence: Dr Yvonne Lim, yve16@hotmail.com

ABSTRACT
Introduction Etoricoxib is a second generation cyclooxygenase-2 inhibitor with a rapid-onset time and a long duration of action. It is ideal for providing pre-emptive analgesia for ambulatory surgeries. We hypothesised that pre-operative etoricoxib can decrease the use of fentanyl post-operatively, when compared with placebo in patients undergoing termination of pregnancy. We also compared their pain scores, time to discharge, side effects and satisfaction with analgesia post-operatively.
Methods After approval by the hospital research ethics committee and receipt of informed written consent, we recruited 40 American Society of Anesthesiologists Physical Status Classification I and II patients scheduled for elective first trimester termination of pregnancy. Patients were randomly allocated to receive either oral etoricoxib 120 mg (Group E, n=20) or placebo tablet (Group P, n=20) pre-operatively. A blinded observer evaluated the post-operative pain scores, need for supplementary analgesia, side effects and satisfaction scores. Sample size was calculated (power of 0.8 and alpha=0.05) to detect a 20 percent difference in fentanyl usage. Amount of fentanyl used, pain scores and satisfaction scores were analysed using non-parametric tests. The incidence of side effects was analysed using chi-squared test.
Results Etoricoxib 120 mg significantly decreased the amount of fentanyl required after termination of pregnancy compared to placebo (0 microg/patient, interquartile range [IQR] 0-25 versus 50 microg/patient, IQR 0-50, p-value is less than 0.05). Patients who received etoricoxib 120 mg also had significantly lower pain scores than the placebo group at time of discharge (8 +/- 11 versus 1 +/- 3, p-value is less than 0.05) and at six hours post operation (8 +/- 12 versus 0 +/- 0, p-value is less than 0.01). There was no difference in their side effects, and time to discharge and overall satisfaction were similar in both groups.
Conclusion Pre-operative administration of oral etoricoxib 120 mg decreased the use of fentanyl and pain scores after minor gynaecological surgery without significant side effects.

Keywords: ambulatory surgical procedures, analgesia, cyclooxygenase inhibitors, etoricoxib, non-steroidal anti-inflammatory drugs
Singapore Med J 2005; 46(8): 397-400

Y Lim, S Jha, AT Sia, N Rawal
Correspondence: Dr Yvonne Lim, yvel6@hotmail.com

ABSTRACT
Introduction Good analgesia is important after a caesarean section but there are no studies to date that compared intrathecal (IT), epidural (EP) and intravenous patient-controlled analgesia (IV PCA) morphine for post-caesarean section analgesia. In this study, we compared the differences in the quality of analgesia and side effects rendered by IT, EP and IV PCA morphine for post-caesarean section analgesia.
Methods We systematically collected and reviewed the data of 949 women who received IT, EP or IV PCA morphine for post-caesarean analgesia during a six-month period. We reviewed the patients 24 hours after surgery and recorded the type of analgesia, the use of adjuncts, pain scores, side effects and degree of satisfaction with the mode of analgesia. The data was captured in an electronic database and analysed.
Results IT morphine was the predominant method of post-caesarean analgesia, accounting for 89.5 percent of the cases. Non-steroidal anti-inflammatory drugs (NSAIDs) were more commonly used in the IT and EP group (IT 76 percent, EP 80 percent and IV PCA 49 percent, p-value is less than 0.05). IT morphine group had a significantly lower pain score at rest (p-value is less than 0.001) and on movement (p-value is less than 0.05) when compared with IV PCA group. EP morphine also resulted in a lower pain score than IV PCA on movement (p-value is less than 0.05). There was no difference in pain scores between EP and IT morphine. In the subgroup analysis of patients who did not receive NSAIDs, IT and EP morphine group also registered lower pain scores at rest and on movement than IV PCA group (p-value is less than 0.05). There was no difference in the satisfaction scores among the three groups.
Conclusion The use of IT and EP morphine was associated with lower pain scores than IV PCA morphine at rest and on movement in the first 24 hours after caesarean section. No severe side effects were found.

Keywords: caesarean section, epidural anaesthesia, morphine, patient-controlled analgesia, spinal anaesthesia
Singapore Med J 2005; 46(8): 392-396

NY Boo, S Selvarani
Correspondence: Professor Nem Yun Boo, nyboo@imu.edu.my

ABSTRACT
Introduction This study aimed to determine the proportions of normothermic infants who remained normothermic, and hypothermic infants who became normothermic following the use of a heated water-filled mattress (HWM) in the labour room.
Methods A prospective observational study carried out in the labour room over a 2.5 month period on 228 well term infants delivered by lower segment caesarean section (LSCS) in the operating theatre (environmental temperature 18 degrees Celsius). Upon arrival in the labour room, the infants were placed on a HWM in a nursing cot. The axillary temperature was measured using a mercury thermometer for three minutes. Each infant was then wrapped with a large piece of linen, and covered with a blanket. Just before transfer to postnatal wards, the axillary temperature was re-measured.
Results 52.2 percent (119/228) of infants were hypothermic (temperature less than 36.5 degrees Celsius) upon arrival in the labour room. Before leaving the labour room, the median increase in axillary temperature of the initially hypothermic infants was significantly higher (0.2 degrees Celsius, interquartile range 0.5) than those initially normothermic infants (0.0 degrees Celsius, interquartile range 0.3) (p-value is less than 0.00001). Among the initially hypothermic infants, 40.3 percent (48/119) became normothermic before transfer to postnatal wards. The significant independent risk factors associated with persistent hypothermia were lower birthweight (p-value equals 0.02), lower gestational age (p-value equals 0.02) and shorter duration on the warming mattress (p-value equals 0.08). Among 109 initially normothermic infants, 17.4 percent became mildly hypothermic (mean axillary temperature 36.2 degrees Celsius, standard deviation 0.2) before leaving the labour room.
Conclusion The HWM is a reasonably effective simple device for the prevention and treatment of hypothermia in the labour room.

Keywords: heated water-filled mattress, labour room, neonatal disorders, neonatal hypothermia
Singapore Med J 2005; 46(8): 387-391