Acute amiodarone syndrome after a single intravenous amiodarone bolus

Ng XR, Wee LY, Chadachan VM
Correspondence: Dr Chadachan Veerendra Melagireppa, Veerendra_Chadachan@ttsh.com.sg

ABSTRACT
Acute amiodarone toxicity after a single dose of intravenous amiodarone is very rarely seen. We report the case of a 64-year-old Chinese man who presented with atrial fibrillation and fluid overload due to congestive cardiac failure. He was treated with a single bolus dose of intravenous amiodarone, after which he developed elevated serum transaminases, coagulopathy, thrombocytopenia and acute renal failure. His parameters returned to normal after 25 days and his recovery was uneventful.

Keywords: acute renal failure, amiodarone, atrial fibrillation, hepatotoxicity, thrombocytopenia
Singapore Med J 2012; 53(11): e225–e227