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Singapore Med J 2013; 54: 185-189 http://dx.doi.org/10.11622/smedj.2013070
Healing the mucosa in Crohn's disease: does it matter?
Ling KL, Chuah SW, Kong SC
Correspondence: Dr Ling Khoon Lin, ling.khoon.lin@sgh.com.sg
ABSTRACT
Clinical remission has been the therapeutic goal of Crohn’s disease treatment for many years. While it has helped to ameliorate the symptoms, this treatment strategy has not brought about significant changes in the need for abdominal surgery in the natural history of Crohn’s disease. The advent of biological agents (biologics) has shown that it is possible to induce and maintain mucosal healing in a significant proportion of treated patients. Data is also emerging to show that this has translated to fewer instances of hospitalisation and surgery for these patients. This is a paradigm shift in the therapeutic goal of Crohn’s disease treatment.
Keywords: Crohn’s disease, drug therapy, mucosal healing
Singapore Med J 2013; 54: 185-189 http://dx.doi.org/10.11622/smedj.2013070
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