Latent Autoimmune Diabetes in Adults (LADA): A Case Series

HH Tan, SC Lim
Correspondence: Dr Tan Hwee Huan, gecthh@sgh.com.sg

ABSTRACT
An adult presenting with diabetes is usually assumed to have type 2 diabetes. Since the 1980s, type 2 diabetic subjects who had failed sulphonylurea therapy soon after diagnosis have been thought to be actually slowly progressive type I patients. This diabetes sub-type is currently referred to as latent autoimmune diabetes in adults (LADA). Early recognition of such patients has important clinical implications. To assist local doctors in the recognition of such patients, we performed a retrospective study to profile and highlight distinctive features of thirteen LADA patients. We found that these patients were mostly females with a mean body mass index of 17.2 kg/m2, diagnosed with type 2 diabetes in their fourth decade of life and becoming insulin dependent after a mean of 2.5 years.

Keywords: latent autoimmune diabetes in adults, anti-GAD antibodies
Singapore Med J 2001; 42(11): 513-516