Chan YS, Ong YS
Correspondence: Dr Dexter Chan, dexter.chan@mohh.com.sg
ABSTRACT
Stroke mimickers are common, and they represent a diagnostic dilemma for clinicians. Many, like posterior reversible encephalopathy syndrome (PRES), are easily reversible. The manifestation of PRES is characterised by headaches, convulsions, altered mental functioning and blindness. In most cases, computed tomography of the brain will show hypodense lesions in the parieto-occpitial lobe, which only further confounds the physician. Although this syndrome is uncommon, prompt and accurate recognition allows early treatment, which has been shown to produce favourable outcomes. Herein, we report the case of a 54-year-old woman, who presented with PRES, as an acute manifestation of systemic lupus erythematous (SLE) and lupus nephritis. The patient was initially thought to be experiencing an ischaemic stroke, but the diagnosis was later changed. On management of her underlying condition, her symptoms resolved. PRES should be recognised as an acute emergency manifestation of SLE. It should not be mistaken for an ischaemic stroke as inappropriate treatment could have adverse outcomes.
Keywords: hypertension, management, posterior reversible encephalopathy syndrome, systemic lupus erythematous
Singapore Med J 2013; 54(9): e193-195; http://dx.doi.org/10.11622/smedj.2013182
REFERENCES
1. Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996; 334:494-500. http://dx.doi.org/10.1056/NEJM199602223340803 |
||||
2. Lee VH, Wijdicks EF, Manno EM, Rabinstein AA. Clinical Spectrum of Reversible Posterior Leukoencephalopathy Syndrome. Arch Neurol 2008; 65:205-10. http://dx.doi.org/10.1001/archneurol.2007.46 |
||||
3. Narbone MC, Musolino R, Granata F, et al. PRES: posterior or potentially reversible encephalopathy syndrome? Neurol Sci 2006; 27:187-9. http://dx.doi.org/10.1007/s10072-006-0667-y |
||||
4. Fujiwara Y, Higaki H, Yamada T, et al. Two cases of reversible posterior leukoencephalopathy syndrome, one with and the other without preeclampsia. J Obstet Gynaecol Res 2005; 31:520-6. http://dx.doi.org/10.1111/j.1447-0756.2005.00345.x |
||||
5. Long TR, Hein BD, Brown MJ, Rydberg CH, Wass CT. Posterior reversible encephalopathy syndrome during pregnancy: seizures in a previously healthy parturient. J Clin Anesth 2007; 19:145-8. http://dx.doi.org/10.1016/j.jclinane.2006.07.004 |
||||
6. Fugate JE, Claassen DO, Cloft HJ, et al. Posterior Reversible Encephalopathy Syndrome: Associated Clinical and Radiologic Findings. Mayo Clin Proc 2010; 85:427-32. http://dx.doi.org/10.4065/mcp.2009.0590 |
||||
7. McKinney AM, Short J, Truwit CL, et al. Posterior reversible encephalopathy syndrome: incidence of atypical regions of involvement and imaging findings. Am J Roentgenol 2007; 189:904-12. http://dx.doi.org/10.2214/AJR.07.2024 |
||||
8. Bartynski WS, Boardman JF. Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol 2007; 28:1320-7. http://dx.doi.org/10.3174/ajnr.A0549 |
||||
9. Kur JK, Esdaile JM. Posterior reversible encephalopathy syndrome—an underrecognized manifestation of systemic lupus erythematosus. J Rheumatol 2006; 33:2178-83. | ||||
10. Leroux G, Sellam J, Costedoat-Chalumeau N, et al. Posterior reversible encephalopathy syndrome during systemic lupus erythematosus: four new cases and review of the literature. Lupus 2008; 17:139-47. http://dx.doi.org/10.1177/0961203307085405 |