Lin CJ, Hung JW, Cho CY, Tseng CY, Chen HY, Lin FC, Li CY
Correspondence: Dr Jen-Wen Hung, hung0702@adm.cgmh.org.tw
ABSTRACT
INTRODUCTION Constipation is a common poststroke complication. This study was designed to document the incidence and clinical course of poststroke constipation in a rehabilitation ward, as well as identify the factors independently associated with the condition.
METHODS This retrospective study involved patients who were admitted to the rehabilitation ward of our institute due to an acute stroke between 1 August 2010 and 31 July 2011. The main outcome measured was the incidence of poststroke constipation, defined as the use of laxative after stroke, fulfilment of the Rome II diagnostic criteria for functional constipation and/or stool impaction. The variables examined were basic demographic data, presence of impairment, degree of disability (evaluated using the Barthel index), walking ability, medications taken and medical complications.
RESULTS Out of the 155 patients who met the inclusion criteria, 123 (79.4%) had poststroke constipation. All 123 patients used oral laxatives; 56 received additional rectal medications and 13 discontinued their use of laxatives at discharge. Patients with poststroke constipation were more likely to have major medical complications (p = 0.04). Those who used rectal medications had a higher risk of major medical complications than those who used only oral laxatives (p < 0.01). Infratentorial lesions were an independent predictor of poststroke constipation (p = 0.003). More severe disability increased the severity of constipation, as indicated by the use of rectal medication.
CONCLUSION Poststroke constipation is a common complication during inpatient rehabilitation. Healthcare providers should be aware of the incidence of poststroke constipation. Further studies are required to establish standard guidelines for screening and managing bowel function in patients with stroke.
Keywords: constipation, incidence, medications, risk factors, stroke
Singapore Med J 2013; 54(11): 624-629; http://dx.doi.org/10.11622/smedj.2013222
REFERENCES
1. Doshi VS, Say JH, Young SH, Doraisamy P. Complications in stroke patients: a study carried out at the Rehabilitation Medicine Service, Changi General Hospital. Singapore Med J 2003; 44:643-52. | ||||
2. Otegbayo JA, Talabi OA, Akere A, et al. Gastrointestinal complications in stroke survivors. Trop Gastroenterol 2006; 27:127-30. | ||||
3. Su Y, Zhang X, Zeng J, et al. New-onset constipation at acute stage after first stroke incidence, risk factors, and impact on the stroke outcome. Stroke 2009; 40:1304-9. http://dx.doi.org/10.1161/STROKEAHA.108.534776 | ||||
4. Bracci F, Badiali D, Pezzotti P, et al. Chronic constipation in hemiplegic patients. World J Gastroenterol 2007; 13:3967-72. | ||||
5. Wiesel PH, Norton C, Brazzelli M. Management of faecal incontinence and constipation in adults with central neurological diseases. Cochrane Database Syst Rev 2001: CD002115. | ||||
6. Krogh K, Christensen P, Laurberg S. Colorectal symptoms in patients with neurological diseases. Acta Neurol Scand 2001; 103:335-43. http://dx.doi.org/10.1034/j.1600-0404.2001.103006335.x | ||||
7. Robain G, Chennevelle JM, Petit F, Piera JB. [Incidence of constipation after recent vascular hemiplegia: a prospective cohort of 152 patients]. Rev Neurol (Paris) 2002; 158:589-92. French. | ||||
8. Thompson WG, Longstreth GF, Drossman DA, et al. Functional bowel disorders and functional abdominal pain. Gut 1999; 45 suppl 2:II43-7. http://dx.doi.org/10.1136/gut.45.2008.ii43 | ||||
9. Stevens TK, Soffer EE, Palmer RM. Fecal incontinence in elderly patients: common, treatable, yet often undiagnosed. Cleve Clin J Med 2003; 70:441- 8. http://dx.doi.org/10.3949/ccjm.70.5.441 | ||||
10. Harari D, Norton C, Lockwood L, Swift C. Treatment of constipation and fecal incontinence in stroke patients: randomized controlled trial. Stroke 2004; 35:2549-55. http://dx.doi.org/10.1161/01.STR.0000144684.46826.62 | ||||
11. Stewart WF, Liberman JN, Sandler RS, et al. Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol 1999; 94:3530-40. http://dx.doi.org/10.1111/j.1572-0241.1999.01642.x | ||||
12. Bassotti G, Bellini M, Pucciani F, et al. An extended assessment of bowel habits in a general population. World J Gastroenterol 2004; 10:713-6. | ||||
13. Winge K, Rasmussen D, Werdelin LM. Constipation in neurological diseases. J Neurol Neurosurg Psychiatry 2003; 74:13-9. http://dx.doi.org/10.1136/jnnp.74.1.13 | ||||
14. Wolfe CD, Taub NA, Woodrow EJ, Burney PG. Assessment of scales of disability and handicap for stroke patients. Stroke 1991; 22:1242-4. http://dx.doi.org/10.1161/01.STR.22.10.1242 | ||||
15. Trindade E, Menon D, Topfer LA, Coloma C. Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. CMAJ 1998; 159:1245-52. | ||||
16. Ueki T, Nagai K, Mizukami Y, et al. Cross-sectional study on relationship between constipation and medication in consideration of sleep disorder. Yakugaku Zasshi 2011; 131:1225-32. http://dx.doi.org/10.1248/yakushi.131.1225 | ||||
17. Hosmer DW, Lemeshow S. Applied Logistic Regression. 2nd ed. New York: Wiley, 2000. http://dx.doi.org/10.1002/0471722146 | ||||
18. Jost WH. [Constipation in neurological diseases]. Z Gastroenterol 2000; suppl 1:14-6. German. | ||||
19. Ullman T, Reding M. Gastrointestinal dysfunction in stroke. Semin Neurol 1996; 16:269-75. http://dx.doi.org/10.1055/s-2008-1040984 | ||||
20. Suares NC, Ford AC. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol 2011; 106:1582-91. http://dx.doi.org/10.1038/ajg.2011.164 | ||||
21. Lazebnik LB, Prilepskaia SI, Baryshnikov EN, Parfenov AI, Kosacheva TN. [Prevalence and risk factors of constipation in the adult population of Moscow (according to population-based study MUSA)]. Eksp Klin Gastroenterol 2011; 68-73. Russian. | ||||
22. Mugie SM, Benninga MA, Di Lorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol 2011; 25:3-18. http://dx.doi.org/10.1016/j.bpg.2010.12.010 | ||||
23. Koch KL. Diabetic gastropathy: gastric neuromuscular dysfunction in diabetes mellitus: a review of symptoms, pathophysiology, and treatment. Dig Dis Sci 1999; 44:1061-75. http://dx.doi.org/10.1023/A:1026647417465 | ||||
24. Bytzer P, Talley NJ, Leemon M, et al. Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med 2001; 161:1989-96. http://dx.doi.org/10.1001/archinte.161.16.1989 | ||||
25. Hung JW, Tsay TH, Chang HW,Leong CP, Lau YC. Incidence and risk factors of medical complications during inpatient stroke rehabilitation. Chang Gung Med J 2005; 28:31-8. | ||||
26. Salmoirago-Blotcher E, Crawford S, Jackson E, Ockene J, Ockene I. Constipation and risk of cardiovascular disease among postmenopausal women. Am J Med 2011; 124:714-23. http://dx.doi.org/10.1016/j.amjmed.2011.03.026 |