Singapore Med J 2013; 54(6): e133-e134; http://dx.doi.org/10.11622/smedj.2013114; Erratum in: Singapore Med J 2014; 55(1): 51.
Docetaxel (Taxotere(R))-induced cavitary change of pulmonary metastatic lesions complicated by bilateral spontaneous pneumothoraces in a patient with primary adenocarcinoma of the lung
Kao HL, Lin WC, Hsu HH, Huang GS
Correspondence: Dr Wen-Chiung Lin, m870877@ndmctsgh.edu.tw
ABSTRACT
Pneumothorax is a complication that rarely occurs after chemotherapy for lung cancer. We report the chest computed tomography findings of a case of spontaneous pneumothorax complicating docetaxel (Taxotere®) treatment for pulmonary metastasis in a 70-year-old woman with pulmonary adenocarcinoma. The patient developed bilateral pneumothoraces, which was induced by changes in the cavitary pulmonary metastatic lesions, after systemic chemotherapy with docetaxel. The chest computed tomography findings and possible mechanisms of this unusual complication are discussed in this report.
Keywords: cavitary change, docetaxel, lung adenocarcinoma, pulmonary metastatic lesions, spontaneous pneumothorax
Singapore Med J 2013; 54(6): e133–e134; http://dx.doi.org/10.11622/smedj.2013114
REFERENCES
1. Steinhäuslin CA, Cuttat JF. Spontaneous pneumothorax. A complication of lung cancer? Chest 1985; 88:709-13.
http://dx.doi.org/10.1378/chest.88.5.709 |
| |
2. Bini A, Zompatori M, Ansaloni L, et al. Bilateral recurrent pneumothorax complicating chemotherapy for pulmonary metastatic breast ductal carcinoma: report of a case. Surg Today 2000; 30:469-72.
http://dx.doi.org/10.1007/s005950050628 |
| |
| 3. Webb WR. Metastatic tumor. In: Webb WR, Higgins CB. Thoracic Imaging: Pulmonary and Cardiovascular Radiology. Philadelphia: Lippincott Williams & Wilkins, 2005: 112-24. |
| |
4. Mori M, Nakagawa M, Fujikawa T, et al. Simultaneous bilateral spontaneous pneumothorax observed during the administration of gefitinib for lung adenocarcinoma with multiple lung metastases. Intern Med 2005; 44:862-4.
http://dx.doi.org/10.2169/internalmedicine.44.862 |
| |
5. Mermershtain W, Schulman H, Hertzanu Y, Cohen Y. Massive cavitation of solid pulmonary metastatic lesions in a breast cancer patient: a case report. Ann Oncol 2002; 13:173-4.
http://dx.doi.org/10.1093/annonc/mdf001 |
| |
6. Thalinger AR, Rosenthal SN, Borg S, Arseneau JC. Cavitation of pulmonary metastases as a response to chemotherapy. Cancer 1980; 46:1329-32.
http://dx.doi.org/10.1002/1097-0142(19800915)46:6<1329::AID-CNCR2820460605>3.0.CO;2-Q |
| |
7. Leslie MD, Napier M, Glaser MG. Pneumothorax as a complication of tumour response to chemotherapy. Clin Oncol (R Coll Radiol) 1993; 5:181-2.
http://dx.doi.org/10.1016/S0936-6555(05)80323-1 |
