The contrasting presentation and management of pseudoangiomatous stromal hyperplasia of the breast

Sng KK, Tan SM, Mancer JFK, Tay KH
Correspondence: Dr Kevin Kaity Sng, kevinksng@gmail.com 

ABSTRACT
Pseudoangiomatous stromal hyperplasia of the breast is a benign entity characterised by dense, collagenous proliferation of mammary stroma, forming interanastomosing capillary-like spaces lined by slender spindle cells. These spaces are not true vascular spaces, hence the term "pseudoangiomatous". We report two 14-year-old girls, who presented to us with pseudoangiomatous stromal hyperplasia of the breast. We believe that our patients represent two of the youngest ethnic Chinese females to be reported with this rare condition. The development of such a rapidly enlarging lesion often leads to anxiety and concern about malignancy, and emphasises the importance in appropriate diagnosis and management. We discuss the aetiology, clinical presentation, radiological and pathological features, as well as management of this unusual condition.

Keywords: collagenous proliferation of mammary stroma, hyperplasia of stromal myofibroblasts, pseudoangiomatous stromal hyperplasia, PASH
Singapore Med J 2008; 49(3):e82-5