Sezary Syndrome in a Malay - Case Report and Literature Review

P Yuen, HL Chan, YS Lee
Corrrespondence: Dr Patricia Yuen

ABSTRACT
Sézary syndrome is a rare form of primary cutaneous T cell lymphoma. It is a distinct systemic variant of mycosis fungoides, marked by erythroderma, lymphadenopathy and circulating cerebriform lymphocytes in the peripheral blood. We report a case of Sézary syndrome in a 61-year-old Malay man with a five-year history of indurated plaques, ulcers and tumours on the head and trunk, with characteristic findings on physical examination, skin biopsy, electron microscopy, immunophenotyping and peripheral blood film. A literature review on Sézary syndrome is presented.

Keywords: erythroderma, lymphadenopathy, cerebriform lymphocytes, mycosis fungoides, tumours
Singapore Med J 2001; 42(5): 224-227