Primary cutaneous nodular amyloidosis initially presenting with eczema

Gan EY, Tey HL
Correspondence: Dr Emily Yiping Gan, emily.ganyp@gmail.com

ABSTRACT
We report an unusual case of a 76-year-old woman with primary cutaneous amyloidosis who initially presented with features of asteatotic eczema that was unresponsive to topical corticosteroid treatment. Histological examination revealed amyloid deposits involving the superficial and deep dermis. These lesions later gradually evolved into erythematous nodules, and a second biopsy performed 29 months after the initial presentation again revealed diffuse collections of amyloid throughout the dermis. Further investigations did not reveal evidence of systemic involvement, thus indicating a diagnosis of primary cutaneous nodular amyloidosis. The initial presentation as eczematous lesions illustrates the importance of clinicopathological correlation and subsequent follow-up.

Keywords: amyloidosis, eczema, nodular
Singapore Med J 2010; 51(9): e158-e160