Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine

Goh TK, Pang SM, Thirumoorthy T, Goh SGN
Correspondence: Dr Goh Teck Kheng, wuzhuqing@yahoo.com

ABSTRACT
Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies. Our patient, a 28-year-old Chinese woman, represents the first known reported case of clinically-consistent and histologically-proven acute generalised exanthematous pustulosis and toxic epidermal necrolysis overlap induced by carbamazepine in the English literature.

Keywords: acute generalised exanthematous pustulosis, carbamazepine, Stevens-Johnson syndrome/toxic epidermal necrolysis overlap
Singapore Med J 2008; 49(6): 507-510